Jordan Williams impressed with 23 points, 12 rebounds and five assists to help the Scorchers pick up their 11th league win in a strong second-half display.
The Giants had made a bright start with Yorick Williams leading his side with nine points as they established a 26-20 advantage.
The lead hit double figures at one stage in the second with Manchester still in control at the half-time break. Surrey were still eight behind at the mid-point in the third before producing a pivotal 13-0 spell to seize the initiative.
The Scorchers carried the momentum into the final period and stormed clear to complete a 14-point victory and move ahead of Bristol Flyers into the coveted eighth spot.
Callum Jones and Yorick Williams finished with 17 points apiece as the Giants drop to 4-22 in the league with their top eight hopes all but over.
Scorchers return to the Sports Park this Saturday for another key game in their BBL Play-Off chase when they welcome the Leeds Force to Guildford for a 7.30pm tip-off. Click here to buy your tickets online now.
Report from bbl.org.uk.